Congratulations (Nikola Ilankovic, 03 January 2012)
It is very interesting!
Congratulations!
Prof.dr Nikola Ilankovic, Belgrade
read full comment
Comment on: Kripke et al. Journal of Circadian Rhythms, 9:8
An interesting article with further scope of research (Priyoneel Basu, 01 July 2011)
An extremely intriguing and interesting discussion, with scope for further research. The following extensions of this study immediately present...
read full comment
Comment on: Soriano et al. Journal of Circadian Rhythms, 8:8
Circadian symptoms and responses (Daniel Kripke, 08 December 2009)
The response of patients to bright light and the circadian expression of bipolar symptoms are some of the evidence supporting the hypothesis that circadian polymorphisms contribute to bipolar disorder.
read full comment
Comment on: Kripke et al. Journal of Circadian Rhythms, 7:2
bipolar disorder linked to circadian clock through sodium (Gregory Marlow, 06 December 2009)
I had bipolar disorder several years ago and I cured it with light therapy and a high salt diet. The light therapy has an obvious connection to the circadian clock – it lengthens daylight. But it took me a while to find how salt was connected. I discovered that in the evening my urine sodium level rose dramatically. This implies that my sodium blood level falls at this time, probably in preparation for sleep. When my sodium level goes below a certain level it causes a condition called hyponatremia which includes mental symptoms. The high salt diet prevents me from going below that critical level and the extra evening light therapy slows down the loss of sodium during the evening hours.
read full comment
Comment on: Kripke et al. Journal of Circadian Rhythms, 7:2
Teaching Chronobiology and Science (John Araujo, 22 June 2009)
This review is one of the best chronobiology paper that I have read. It discuss carefully the most important chronobiology concept and it teach us how to make a good and serious Science.
read full comment
Re: Missing Nighttime Light Exposure? (J. Bullough, 29 July 2008)
It is standard protocol that participants should wear the device if they get up during normal sleep hours (e.g., to use the bathroom) so such light exposures would be measured. See for example the bottom panel of Figure 1 from a related paper (Figueiro et al. 2006) where the Daysimeter was used.
read full comment
Comment on: Rea et al. Journal of Circadian Rhythms, 6:7
Missing Nighttime Light Exposure? (Berndette Chasteen, 26 July 2008)
This new technique for studying the effects of circadian disruption is a wonderful step forward for our understanding of this important area of human health. I just worry that having the Daysimeter device left next to the subject during sleep hours will miss critical nighttime light exposure when the subject gets up in the night (e.g. turning on a bathroom light or passing a window which admits streetlight).
read full comment
Comment on: Rea et al. Journal of Circadian Rhythms, 6:7
A balance of factors (Daniel Kripke, 23 August 2007)
Dr. Zivkovic is absolutely right that we might expect the circadian oscillators of older adults to be weaker, and for that reason, easier to phase shift. That is, weaker amplitude in overt circadian rhythms could reflect a lower amplitude central pacemaker leading theoretically to higher-amplitude phase-response curves [1-2]. One indication that older people have weaker oscillators is the lower overt amplitude of many rhythms such as body temperature, activity, and melatonin. Another indication may be the longer duration of melatonin secretion observed, as this may be analogous to increased melatonin duration and activity time (α) in nocturnal rodents [3]. Increased duration of nocturnal wheel-running in hamsters corresponds to a circadian pacemaker which is easier to shift [4,5]...
read full comment
Comment on: Kripke et al. Journal of Circadian Rhythms, 5:4
Nice paper, but I have one little question (Bora Zivkovic, 01 August 2007)
This work is well thought-out and well done. I do not think that the negative result (i.e., no difference between young and old) is a reason to despair - I find it quite informative. I have explained in more detail here:The Amplitude ProblemWill all the data (e.g., temperature PRC, etc.) be available as Supplementary Information?Finally, is it a mistake that you expected a smaller sizes of phase-shifts in a lower-amplitude system? Shouldn't you expect greater shifts when the amplitude is lower?
read full comment
Comment on: Kripke et al. Journal of Circadian Rhythms, 5:4
Reply to Professor Kats' query (Roberto Refinetti, 15 May 2005)
Professor Halberg, as the author of the referenced article, may have a different answer, but my feeling is that more information about the problem is needed before a solution can be sought. In principle, the desynchrony between the circadian clock and the outside clock caused by transmeridian travel could have many effects, including the reported worsening of tremor activity. However, the fact that the tremor improves in a few hours upon return home suggests that circadian desynchrony is not the central issue. More likely, the worsening of tremor activity is an acute effect of the trip (pressure changes in the airplane, change in weather from origin to destination, air-borne allergens, etc.). As for the question of whether targeting genes that encode the proteins governing circadian rhythms...
read full comment
Comment on: Halberg et al. Journal of Circadian Rhythms, 1:2
circadian tremor-activating mechanism in ET (Bernhard A Kats, 14 May 2005)
My Groups MDOET · ET2005 From: "Bernhard A Kats" <quibi02@yahoo.com> Date: Sat May 14, 2005 8:17 am Several patients have reported to me worsening of tremor activity when crossing severaltime-zones from East to West, like flying from Europe to the US. This change occurs gradually in the course of 48 hours, regardless of the season. When flying home from West to East, the tremor improves in a few hours.This suggests involvement of the hypothalamus, specifically the suprachiasmatic nucleus or biological "clock", that controls the body's circadian rhythms.Questions: Could a melatonin agonist like the research drug LY 156735 speed up this readaptation time?Or could targeting genes that encode the proteins governing circadian rhythmsand that affect this adaptability yield...
read full comment
Comment on: Halberg et al. Journal of Circadian Rhythms, 1:2
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Latest comments
Congratulations (Nikola Ilankovic, 03 January 2012)
It is very interesting!
Congratulations!
Prof.dr Nikola Ilankovic, Belgrade read full comment
Comment on: Kripke et al. Journal of Circadian Rhythms, 9:8
An interesting article with further scope of research (Priyoneel Basu, 01 July 2011)
An extremely intriguing and interesting discussion, with scope for further research. The following extensions of this study immediately present... read full comment
Comment on: Soriano et al. Journal of Circadian Rhythms, 8:8
Circadian symptoms and responses (Daniel Kripke, 08 December 2009)
The response of patients to bright light and the circadian expression of bipolar symptoms are some of the evidence supporting the hypothesis that circadian polymorphisms contribute to bipolar disorder. read full comment
Comment on: Kripke et al. Journal of Circadian Rhythms, 7:2
bipolar disorder linked to circadian clock through sodium (Gregory Marlow, 06 December 2009)
I had bipolar disorder several years ago and I cured it with light therapy and a high salt diet. The light therapy has an obvious connection to the circadian clock – it lengthens daylight. But it took me a while to find how salt was connected. I discovered that in the evening my urine sodium level rose dramatically. This implies that my sodium blood level falls at this time, probably in preparation for sleep. When my sodium level goes below a certain level it causes a condition called hyponatremia which includes mental symptoms. The high salt diet prevents me from going below that critical level and the extra evening light therapy slows down the loss of sodium during the evening hours. read full comment
Comment on: Kripke et al. Journal of Circadian Rhythms, 7:2
Teaching Chronobiology and Science (John Araujo, 22 June 2009)
This review is one of the best chronobiology paper that I have read. It discuss carefully the most important chronobiology concept and it teach us how to make a good and serious Science. read full comment
Comment on: Mistlberger et al. Journal of Circadian Rhythms, 7:3
Re: Missing Nighttime Light Exposure? (J. Bullough, 29 July 2008)
It is standard protocol that participants should wear the device if they get up during normal sleep hours (e.g., to use the bathroom) so such light exposures would be measured. See for example the bottom panel of Figure 1 from a related paper (Figueiro et al. 2006) where the Daysimeter was used. read full comment
Comment on: Rea et al. Journal of Circadian Rhythms, 6:7
Missing Nighttime Light Exposure? (Berndette Chasteen, 26 July 2008)
This new technique for studying the effects of circadian disruption is a wonderful step forward for our understanding of this important area of human health. I just worry that having the Daysimeter device left next to the subject during sleep hours will miss critical nighttime light exposure when the subject gets up in the night (e.g. turning on a bathroom light or passing a window which admits streetlight). read full comment
Comment on: Rea et al. Journal of Circadian Rhythms, 6:7
A balance of factors (Daniel Kripke, 23 August 2007)
Dr. Zivkovic is absolutely right that we might expect the circadian oscillators of older adults to be weaker, and for that reason, easier to phase shift. That is, weaker amplitude in overt circadian rhythms could reflect a lower amplitude central pacemaker leading theoretically to higher-amplitude phase-response curves [1-2]. One indication that older people have weaker oscillators is the lower overt amplitude of many rhythms such as body temperature, activity, and melatonin. Another indication may be the longer duration of melatonin secretion observed, as this may be analogous to increased melatonin duration and activity time (α) in nocturnal rodents [3]. Increased duration of nocturnal wheel-running in hamsters corresponds to a circadian pacemaker which is easier to shift [4,5]... read full comment
Comment on: Kripke et al. Journal of Circadian Rhythms, 5:4
Nice paper, but I have one little question (Bora Zivkovic, 01 August 2007)
This work is well thought-out and well done. I do not think that the negative result (i.e., no difference between young and old) is a reason to despair - I find it quite informative. I have explained in more detail here:The Amplitude ProblemWill all the data (e.g., temperature PRC, etc.) be available as Supplementary Information?Finally, is it a mistake that you expected a smaller sizes of phase-shifts in a lower-amplitude system? Shouldn't you expect greater shifts when the amplitude is lower? read full comment
Comment on: Kripke et al. Journal of Circadian Rhythms, 5:4
Reply to Professor Kats' query (Roberto Refinetti, 15 May 2005)
Professor Halberg, as the author of the referenced article, may have a different answer, but my feeling is that more information about the problem is needed before a solution can be sought. In principle, the desynchrony between the circadian clock and the outside clock caused by transmeridian travel could have many effects, including the reported worsening of tremor activity. However, the fact that the tremor improves in a few hours upon return home suggests that circadian desynchrony is not the central issue. More likely, the worsening of tremor activity is an acute effect of the trip (pressure changes in the airplane, change in weather from origin to destination, air-borne allergens, etc.). As for the question of whether targeting genes that encode the proteins governing circadian rhythms... read full comment
Comment on: Halberg et al. Journal of Circadian Rhythms, 1:2
circadian tremor-activating mechanism in ET (Bernhard A Kats, 14 May 2005)
My Groups MDOET · ET2005 From: "Bernhard A Kats" <quibi02@yahoo.com> Date: Sat May 14, 2005 8:17 am Several patients have reported to me worsening of tremor activity when crossing severaltime-zones from East to West, like flying from Europe to the US. This change occurs gradually in the course of 48 hours, regardless of the season. When flying home from West to East, the tremor improves in a few hours.This suggests involvement of the hypothalamus, specifically the suprachiasmatic nucleus or biological "clock", that controls the body's circadian rhythms.Questions: Could a melatonin agonist like the research drug LY 156735 speed up this readaptation time?Or could targeting genes that encode the proteins governing circadian rhythmsand that affect this adaptability yield... read full comment
Comment on: Halberg et al. Journal of Circadian Rhythms, 1:2