Table 2

Association of ASMT rs4446909 with depression scales.

Study

rs4446909 P

rs4446909 R²

rs4446909 Beta

DSPD

0.01

0.007

-0.74

Sleep Clinic

0.10

0.004

0.40

MrOS

0.06

0.0003

0.02*

SOF

0.26

.0006

0.01*

P: nominal values, corrected for genomic inflation, are for additive association of the minor allele of rs4446909 with the QIDS or GDS depression self-rating. Recessive models were not more significant.

R²: squared correlation representing percent variance explained by the association of the depression score and rs4446909, uncorrected for covariates.

Beta: for DSPD, a negative beta indicated that as the A allele decreases in amount (frequency), and G alleles increase, QIDS depression scores increase. The not-significant Beta's for the Sleep Clinic, MrOS, and SOF participants were in the opposite direction from the DSPD sample.

* Beta for the log transform of GDS+1 suggested a 2% increase in GDS score over the range of 1 to 16 per A allele.

Kripke et al. Journal of Circadian Rhythms 2011 9:8   doi:10.1186/1740-3391-9-8