Table 3 |
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|
Chronobiological data derived from best fitting sine curves (fitted period:24 hours = 360°) |
|||||
|
Healthy young-middle aged subjects |
|||||
|
Factor |
p |
MESOR ± SE |
Amplitude ± SE |
Acrophase ± SE(°) |
Time (Hh:Mn) |
|
|
|||||
|
CD3 |
0.002 |
78.06 ± 0.10 |
1.12 ± 0.22 |
25.1 ± 12.4 |
01:40 ± 00:50 |
|
CD4 |
0.001 |
45.23 ± 0.85 |
3.14 ± 1.12 |
3.3 ± 24.5 |
00:13 ± 01:38 |
|
CD8 |
0.003 |
29.52 ± 0.23 |
1.94 ± 0.25 |
181.3 ± 2.4 |
12:05 ± 00:10 |
|
CD8 bright |
0.001 |
21.43 ± 0.11 |
1.49 ± 0.21 |
187.3 ± 10.2 |
12:29 ± 00:41 |
|
CD8 dim |
0.002 |
8.09 ± 0.14 |
1.33 ± 0.09 |
192.1 ± 3.8 |
12:48 ± 00:15 |
|
CD4/CD8 ratio |
0.001 |
1.53 ± 0.02 |
0.23 ± 0.1 |
16.0 ± 0.2 |
01:04 ± 00:01 |
|
CD16 |
0.030 |
6.26 ± 0.42 |
0.81 ± 0.21 |
212.1 ± 21.3 |
14:08 ± 01:25 |
|
CD20 |
0.002 |
13.23 ± 0.24 |
1.51 ± 0.11 |
336.8 ± 12.2 |
22:27 ± 00:49 |
|
CD25 |
0.002 |
3.82 ± 0.02 |
0.67 ± 0.21 |
9.2 ± 7.1 |
00:37 ± 00:28 |
|
DR+T cells |
0.005 |
3.21 ± 0.30 |
0.83 ± 0.20 |
12.2 ± 51.2 |
00:49 ± 03:25 |
|
HLA-DR |
0.010 |
16.22 ± 0.25 |
1.33 ± 0.33 |
332.6 ± 11.3 |
22:10 ± 00:45 |
|
TcRδ1 |
0.002 |
2.12 ± 0.09 |
0.63 ± 0.12 |
159.5 ± 14.3 |
10:38 ± 00:57 |
|
Cortisol |
0.001 |
10.23 ± 1.42 |
6.51 ± 2.52 |
141.6 ± 22.1 |
09:26 ± 01:28 |
|
Old aged subjects |
|||||
|
Factor |
p |
MESOR ± SE |
Amplitude ± SE |
Acrophase ± SE (°) |
Time (Hh:Mn) |
|
CD3 |
0.002 |
84.91 ± 0.21 |
1.07 ± 0.02 |
71.2 ± 3.0 |
04:45 ± 00:12 |
|
CD4 |
0.145 |
45.12 ± 0.89 |
3.10 ± 1.27 |
33.2 ± 22.1 |
02:13 ± 01:28 |
|
CD8 |
0.005 |
29.21 ± 0.23 |
3.25 ± 0.53 |
188.9 ± 11.2 |
12:36 ± 00:45 |
|
CD8 bright |
0.001 |
20.12 ± 0.08 |
1.47 ± 0.19 |
196.1 ± 12.3 |
13:04 ± 00:49 |
|
CD8 dim |
0.002 |
9.09 ± 0.15 |
1.31 ± 0.87 |
191.7 ± 2.4 |
12:47 ± 00:10 |
|
CD4/CD8 ratio |
0.001 |
1.48 ± 0.06 |
0.22 ± 0.04 |
17.9 ± 11.7 |
01:12 ± 00:47 |
|
CD16 |
0.246 |
8.02 ± 0.31 |
2.42 ± 0.43 |
191.3 ± 7.5 |
12:45 ± 00:30 |
|
CD20 |
0.210 |
8.36 ± 0.16 |
1.15 ± 0.11 |
287.2 ± 21.4 |
19:09 ± 01:26 |
|
CD25 |
0.031 |
7.12 ± 0.13 |
1.02 ± 0.21 |
251.2 ± 12.3 |
16:45 ± 00:49 |
|
DR+T cells |
0.057 |
5.12 ± 0.35 |
1.73 ± 0.2 |
141 ± 11.2 |
09:24 ± 00:45 |
|
HLA-DR |
0.297 |
13.21 ± 0.12 |
1.21 ± 0.9 |
185.1 ± 33.2 |
12:20 ± 02:13 |
|
TcRδ1 |
0.210 |
4.28 ± 0.12 |
0.32 ± 0.11 |
192.1 ± 30.4 |
12:48 ± 02:02 |
|
Cortisol |
0.017 |
13.26 ± 0.40 |
5.42 ± 1.31 |
121.8 ± 10.2 |
08:07 ± 00:40 |
|
|
|||||
|
Units: % for lymphocyte subpopulations, g/dl for cortisol, all parameters analyzed in all the subjects |
|||||
|
Mazzoccoli et al. Journal of Circadian Rhythms 2010 8:6 doi:10.1186/1740-3391-8-6 |
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