Table 6

Haplotype association analysis of CLOCK.

SNP block

Haplotype

Sample set

Overall frequency

OR (95% CI)

P-value

rs3805151-rs2412648-rs11240-rs2412646

TTGC

1.

0.34

1.65 (1.14-2.28)

0.0077

2.

0.33

Ns

Ns

3.

0.34

1.50 (1.14-2.27)

0.0084

rs11240-rs2412646

GC

1.

0.34

1.65 (1.15-2.29)

0.0077

2.

0.28

Ns

Ns

3.

0.34

1.50 (1.14-2.27)

0.0084

Ns = non significant (P > 0.1). Odds ratio (OR): the ratio specific haplotype versus all other haplotypes among the cases, relative to the ratio specific haplotype versus all other haplotypes among the controls. Gender was used as covariate.

Sjöholm et al. Journal of Circadian Rhythms 2010 8:1   doi:10.1186/1740-3391-8-1