Table 1 |
|||||
|
Methods used in recent papers examining non-traditional circadian oscillators. |
|||||
| Study |
Lesion type |
Done in DD? |
Measure of Entrainment |
Deprivation period |
Homeostatic increase in measure? |
|
|
|||||
| Clock gene deletion studies in RF |
|||||
| Fuller et al., 2008 (2) |
Bmal1 ko |
DD |
Tb and LMA |
Yes, 24 hrs, no anticipation in RF |
No, reduced Tb and LMA |
| Mistlberger al., 2008 (9) |
Bmal1 ko |
Mainly DD |
Motion sensor |
Ad lib after RF shows no entrainment |
Yes, increased activity in RF |
| Pendergast et al., 2009 (11) |
Bmal1 ko |
LD and DD |
Wheel running |
Yes, 48 hrs, no clear entrainment |
Yes, increased running in RF and food deprivation |
| Storch and Weitz, 2009 (10) |
multiple clock genes |
LD and DD |
Wheel running |
Not done |
Yes, increased running in RF |
| Clock gene deletion study in MASCO |
|||||
| Mohawk et al., 2009 (15) |
Multiple clock genes |
Mainly DD |
Motion sensor for Bmal1; wheel running for rest |
Not done |
Yes, increased running after MA ingestion |
| DMH lesion studies in RF |
|||||
| Gooley et al., 2006 (8) |
excitotoxic |
LD only |
Tb and LMA |
Yes, 44 hrs, after RF |
No, reduced Tb and LMA in RF |
| Landry et al., 2006 (5) |
electrolytic |
LD only |
Motion sensor |
Yes, 51 hrs after RF |
Yes, increased activity in RF |
| Landry et al., 2007 (4) |
electrolytic |
LD only |
Motion sensor |
Yes, 72 hrs after RF |
Yes, increased activity in RF |
| Moriya et al., 2009 (6) |
electrolytic |
LD, + DD test days |
Motion sensor Tb, LMA |
Yes, 46 or 58 hrs, but only first day shown |
Does not say (activity normalized) |
|
|
|||||
|
Fuller et al. Journal of Circadian Rhythms 2009 7:9 doi:10.1186/1740-3391-7-9 |
|||||
