Figure 1 .

Rectal temperature (°C) variation according to the circadian time (1, 5, 9, 13, 17 and 21 HALO) of VPA administration (850 mg / kg,i.p.) in a total of 90 mice on day 1 before treatment, and on days 3, 5, 9 and 15 following treatment in surviving mice. Differences related to both dosing-time and sampling-day were statistically validated by one-way ANOVA (p ≤ 0.01).