Transdisciplinary unifying implications of circadian findings in the 1950s

Franz Halberg¹ , Germaine Cornélissen¹ , George Katinas¹ , Elena V Syutkina² , Robert B Sothern¹ , Rina Zaslavskaya³ , Francine Halberg¹ , Yoshihiko Watanabe⁴ , Othild Schwartzkopff¹ , Kuniaki Otsuka⁵ , Roberto Tarquini⁶ , Perfetto Frederico⁶ and Jarmila Siggelova⁷

¹Halberg Chronobiology Center, University of Minnesota, Minneapolis, MN, USA

²Institute of Pediatrics, Scientific Center for Children's Health, Academy of Medical Sciences, Moscow, Russia

³Department of Cardiology, Hospital #60, Moscow, Russia

⁴Tokyo Women's Medical University, Daini Hospital, Tokyo, Japan

⁵Tokyo Women Medical University, School of Medicine, Daini Hospital, Division of Neurocardiology and Chronoecology, Nishiogu 2-1-10, Arakawa-ku, Tokyo 116-856, Japan

⁶Department of Internal Medicine, University of Florence, Italy

⁷Clinic of Functional Diagnostics and Rehabilitation, St. Anna Faculty Hospital and Masaryk University of Brno, Pekaská 53, 656 91, Brno, Czech Republic

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Journal of Circadian Rhythms 2003, 1:2doi:10.1186/1740-3391-1-2


Published:	29 October 2003

Abstract

A few puzzles relating to a small fraction of my endeavors in the 1950s are summarized herein, with answers to a few questions of the Editor-in-Chief, to suggest that the rules of variability in time complement the rules of genetics as a biological variability in space. I advocate to replace truisms such as a relative constancy or homeostasis, that have served bioscience very well for very long. They were never intended, however, to lower a curtain of ignorance over everyday physiology. In raising these curtains, we unveil a range of dynamics, resolvable in the data collection and as-one-goes analysis by computers built into smaller and smaller devices, for a continued self-surveillance of the normal and for an individualized detection of the abnormal. The current medical art based on spotchecks interpreted by reference to a time-unqualified normal range can become a science of time series with tests relating to the individual in inferential statistical terms. This is already doable for the case of blood pressure, but eventually should become possible for many other variables interpreted today only based on the quicksand of clinical trials on groups. These ignore individual differences and hence the individual's needs. Chronomics (mapping time structures) with the major aim of quantifying normalcy by dynamic reference values for detecting earliest risk elevation, also yields the dividend of allowing molecular biology to focus on the normal as well as on the grossly abnormal.